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Vibrational spectroscopy; Spectral imaging for Bioanalytics and Diagnostics; Biosensing; Nanostructured devices


Master Degree in Quantum Optics at the University of Rome "La Sapienza" and Ph.D. in physics in 2003 at the University Roma Tre. In the following years, she directed the research activity aimed at the development of biosensors and nanostructured devices for biomedical applications at NANOMED laboratories, at the Department of Physics of the University of Genova, where she also conducted teaching activities at the Faculty of Arts and Philosophy (Physics for Cultural Heritage) and Medicine. Since November 2012, she is a research scientist at the National Research Council, CNR, in the Area of Roma Tor Vergata (first in the Institute of Complex Systems, ISC, then, from 2017, in the Institute of Microelectronics and Microsystems, IMM) where she works on the use of vibrational micro-spectroscopy for bioanalytical and diagnostic applications. She is the author of numerous articles published in international journals (http://publicationslist.org/vale_nena) and of two patents relating to nanoscale biosensors for nanomedicine applications. In October 2010, she contributed to the foundation of the spin-off of the University of Genova "Nanomed Srl", and in 2013 she obtained the National Scientific Qualification for Associate Professor. Since 2013, she coordinates the CNR inter-departmental Virtual Laboratory Tech4Bio (www.tech4bio.eu), which includes several Institutes (IMM, IFN, IFT, ISM) and brings together skills and facilities in the field of Life Science: biosensors, biochemistry, microscopy, spectroscopy, advanced microfluidic devices and lab-on-chip development for bioanalytics and diagnostics, micro and nano-scale characterization, design and study of new smart biomaterials. From July 2014 to September 2017 she was responsible for the Supporting Organizational Unit of the Institute of Complex Systems of CNR in the Rome Research Area of Tor Vergata, UOS ISC RM2. She is an expert evaluator for H2020-FETOPEN-2016-2017-RIA, for the Italian Ministry for Economic Development and for the Ministry of University and Research. She is a member of the organizing committee of the "Biophysics@Rome" (www.biophysicsatrome.org) periodical conference, and since 2015 she is member of the European COST Action Raman4Clinics (www.cost.eu/COST_Actions/bmbs/BM1401).


Scientific Productions

Antonio Ferraro, Pino Cerza, Valentina Mussi, Luca Maiolo, Annalisa Convertino, Roberto Caputo

Efficient Photothermal Generation by Nanoscale Light Trapping in a Forest of Silicon Nanowires

The Journal of Physical Chemistry C [American Chemical Society],

Antonio Valletta, Valentina Mussi, Matteo Rapisarda, Andrea Lucibello, Marco Natali, Marco Peroni, Claudio Lanzieri, Guglielmo Fortunato, Luigi Mariucci

Hybrid Electrothermal Simulations of GaN HEMT Devices Based on Self-Heating Free Virtual Electrical Characteristics

IEEE Transactions on Electron Devices [IEEE],

Sara De Simone, Ana Perošević-Bajčeta, Danijela Joksimović, Romeo Beccherelli, Dimitrios C Zografopoulos, Valentina Mussi

Study of Microplastics and Inorganic Contaminants in Mussels from the Montenegrin Coast, Adriatic Sea

Journal of Marine Science and Engineering [Multidisciplinary Digital Publishing Institute], Volume: 9 Issue: 5 Pages: 544

Federica Valentini, Pasquino Pallecchi, Michela Relucenti, Orlando Donfrancesco, Gianluca Sottili, Ida Pettiti, Valentina Mussi

Characterization of Calcium Carbonate Nanoparticles with Architectural Application for the Consolidation of Pietraforte

Analytical Letters [Taylor & Francis], Pages: 1-16

Valentina Mussi, Mario Ledda, Davide Polese, Luca Maiolo, Debadrita Paria, Ishan Barman, Maria Grazia Lolli, Antonella Lisi, Annalisa Convertino

Silver-coated silicon nanowire platform discriminates genomic DNA from normal and malignant human epithelial cells using label-free Raman spectroscopy

Materials Science and Engineering: C [Elsevier], Volume: 122 Pages: 111951

Valentina Mussi, Mario Ledda, Annalisa Convertino, Antonella Lisi

Raman Mapping of Biological Systems Interacting with a Disordered Nanostructured Surface: A Simple and Powerful Approach to the Label-Free Analysis of Single DNA Bases

Micromachines [Multidisciplinary Digital Publishing Institute], Volume: 12 Issue: 3 Pages: 264

Aswathi K Sivan, Lorenzo Di Mario, Yunyan Zhang, Daniele Catone, Patrick OKeeffe, Stefano Turchini, Valentina Mussi, Huiyun Liu, Faustino Martelli

Diameter dependence of the temperature dynamics of hot carriers in photoexcited GaAsP nanowires

arXiv preprint arXiv:2102.05471 [],

Debadrita Paria, Annalisa Convertino, Valentina Mussi, Luca Maiolo, Ishan Barman

Silver‐Coated Disordered Silicon Nanowires Provide Highly Sensitive Label‐Free Glycated Albumin Detection through Molecular Trapping and Plasmonic Hotspot Formation

Advanced Healthcare Materials [], Volume: 10 Issue: 3 Pages: 2001110

E Lenzi, S Dinarelli, G Longo, M Girasole, V Mussi

Multivariate Analysis of mean Raman spectra of erythrocytes for a fast analysis of the biochemical signature of ageing

Talanta [Elsevier], Volume: 221 Pages: 121442

Federico Berto, Niloofar Haghighian, Katja Ferfolja, Sandra Gardonio, Mattia Fanetti, Faustino Martelli, Valentina Mussi, Vladimir G Dubrovskii, Igor V Shtrom, Alfonso Franciosi, Silvia Rubini

Ga2Se3 Nanowires via Au-Assisted Heterovalent Exchange Reaction on GaAs

The Journal of Physical Chemistry C [American Chemical Society], Volume: 124 Issue: 32 Pages: 17783-17794

Annalisa D’Arco, Valentina Mussi, Stefan Petrov, Silvia Tofani, Massimo Petrarca, Romeo Beccherelli, Dimitre Dimitrov, Vera Marinova, Stefano Lupi, Dimitrios C Zografopoulos

Fabrication and spectroscopic characterization of graphene transparent electrodes on flexible cyclo-olefin substrates for terahertz electro-optic applications

Nanotechnology [IOP Publishing], Volume: 31 Issue: 36 Pages: 364006

Alessandro Paolini, Giulia Battafarano, Valentina D’oria, Francesco Mura, Simona Sennato, Valentina Mussi, Roberta Risoluti, Stefano Materazzi, Andrea Del Fattore, Andrea Masotti

A 3D-Printed Multi-Chamber Device Allows Culturing Cells On Buckypapers Coated With PAMAM Dendrimer And Obtain Innovative Materials For Biomedical Applications

International journal of nanomedicine [Dove Press], Volume: 14 Pages: 9295

Francesca Ceccacci, Simona Sennato, Edoardo Rossi, Raffaele Proroga, Stefano Sarti, Marco Diociaiuti, Stefano Casciardi, Valentina Mussi, Alessia Ciogli, Federico Bordi, Giovanna Mancini, Cecilia Bombelli

Aggregation behaviour of triphenylphosphonium bolaamphiphiles

Journal of colloid and interface science [Academic Press], Volume: 531 Pages: 451-462

S Dinarelli, G Longo, S Krumova, S Todinova, A Danailova, SG Taneva, E Lenzi, V Mussi, M Girasole

Insights into the morphological pattern of erythrocytes' aging: Coupling quantitative AFM data to microcalorimetry and Raman spectroscopy

Journal of Molecular Recognition [], Volume: 31 Issue: 11 Pages: e2732

Luca Pazzini, Loredana Cerroni, Guido Pasquantonio, Alessandro Pecora, Valentina Mussi, Antonio Rinaldi, Barbara Mecheri, Silvia Licoccia, Luca Maiolo

Mechanical properties of “two generations” of teeth aligners: Change analysis during oral permanence

Dental materials journal [The Japanese Society for Dental Materials and Devices], Volume: 37 Issue: 5 Pages: 835-842

Annalisa Convertino, Valentina Mussi, Luca Maiolo, Mario Ledda, Maria Grazia Lolli, Fabio Antonio Bovino, Guglielmo Fortunato, Massimiliano Rocchia, Antonella Lisi

Array of disordered silicon nanowires coated by a gold film for combined NIR photothermal treatment of cancer cells and Raman monitoring of the process evolution

Nanotechnology [IOP Publishing], Volume: 29 Issue: 41 Pages: 415102

M Pea, G Barucca, A Notargiacomo, L Di Gaspare, V Mussi

Zn nanoparticle formation in FIB irradiated single crystal ZnO

Applied Surface Science [North-Holland], Volume: 433 Pages: 899-903

Valentina Mussi

Nanostructured substrates for biomedical applications

Edorium Open [], Volume: 1 Pages: 4-8

Valentina Mussi

Nanostructured substrates for biomedical applications

Edorium Open [], Volume: 1 Pages: 4-8

M Pea, G Barucca, A Notargiacomo, L Di Gaspare, V Mussi

Zn nanoparticle formation in FIB irradiated single crystal ZnO

Applied Surface Science [North-Holland],

R Condò, L Cerroni, G Pasquantonio, M Mancini, A Pecora, A Convertino, V Mussi, A Rinaldi, L Maiolo

A Deep Morphological Characterization and Comparison of Different Dental Restorative Materials

BioMed research international [Hindawi], Volume: 2017

E Petronijevic, G Leahu, V Mussi, C Sibilia, FA Bovino

Photoacoustic technique for the characterization of plasmonic properties of 2D periodic arrays of gold nanoholes

AIP Advances [AIP Publishing LLC], Volume: 7 Issue: 2 Pages: 025210

M Pea, V Mussi, G Barucca, E Giovine, A Rinaldi, R Araneo, A Notargiacomo

Focused ion beam surface treatments of single crystal zinc oxide for device fabrication

Materials & Design [Elsevier], Volume: 112 Pages: 530-538

Francesca R Bertani, Elisabetta Botti, Luisa Ferrari, Valentina Mussi, Antonio Costanzo, Marco D'Alessandro, Francesco Cilloco, Stefano Selci

Label‐free and non‐invasive discrimination of HaCaT and melanoma cells in a co‐culture model by hyperspectral confocal reflectance microscopy

Journal of biophotonics [WILEY‐VCH Verlag], Volume: 9 Issue: 6 Pages: 619-625

Annalisa Convertino, Valentina Mussi, Luca Maiolo

Disordered array of Au covered Silicon nanowires for SERS biosensing combined with electrochemical detection

Scientific reports [Nature Publishing Group], Volume: 6 Issue: 1 Pages: 1-10

Paola Fanzio, Valentina Mussi, Michele Menotta, Giuseppe Firpo, Luca Repetto, Patrizia Guida, Elena Angeli, Mauro Magnani, Ugo Valbusa

Selective protein detection with a dsLNA-functionalized nanopore

Biosensors and Bioelectronics [Elsevier], Volume: 64 Pages: 219-226

Sonja Visentin, Nadia Barbero, Francesca Romana Bertani, Mariangela Cestelli Guidi, Giuseppe Ermondi, Guido Viscardi, Valentina Mussi

Multivariate analysis applied to Raman mapping of dye-functionalized carbon nanotubes: a novel approach to support the rational design of functional nanostructures

Analyst [Royal Society of Chemistry], Volume: 140 Issue: 16 Pages: 5754-5763

Elena Angeli, Valentina Mussi, Paola Fanzio, Chiara Manneschi, Luca Repetto, Giuseppe Firpo, Patrizia Guida, Vincenzo Ierardi, Andrea Volpe, Ugo Valbusa

Micro and nanofluidic platforms for advanced diagnostics

Edorium J Nanotechnol [], Volume: 1 Pages: 1-7

FR Bertani, E Botti, A Costanzo, L Ferrari, V Mussi, M D’Alessandro, S Selci

Label-free discrimination of cells undergoing apoptosis by hyperspectral confocual reflectance imaging

Journal of the European Optical Society-Rapid publications [], Volume: 8

Francesca R Bertani, Luisa Ferrari, Valentina Mussi, Elisabetta Botti, Antonio Costanzo, Stefano Selci

Living matter observations with a novel hyperspectral supercontinuum confocal microscope for VIS to near-IR reflectance spectroscopy

Sensors [Multidisciplinary Digital Publishing Institute], Volume: 13 Issue: 11 Pages: 14523-14542

Chiara Manneschi, Paola Fanzio, Elena Angeli, Giuseppe Firpo, Luca Ceseracciu, Valentina Mussi, Luca Repetto, Ugo Valbusa

Mechanical squeezing of an elastomeric nanochannel device: numerical simulations and ionic current characterization

Microfluidics and nanofluidics [Springer-Verlag], Volume: 14 Issue: 1-2 Pages: 21-30

Paola Fanzio, Chiara Manneschi, Elena Angeli, Valentina Mussi, Giuseppe Firpo, Luca Ceseracciu, Luca Repetto, Ugo Valbusa

Modulating DNA translocation by a controlled deformation of a PDMS nanochannel device

Scientific reports [Nature Publishing Group], Volume: 2 Issue: 1 Pages: 1-6

Valentina Mussi, Paola Fanzio, Giuseppe Firpo, Luca Repetto, Ugo Valbusa

Size and functional tuning of solid state nanopores by chemical functionalization

Nanotechnology [IOP Publishing], Volume: 23 Issue: 43 Pages: 435301

Silvia Tagliapietra, Giancarlo Cravotto, Emanuela Calcio Gaudino, Sonja Visentin, Valentina Mussi

Functionalization of single-walled carbon nanotubes through 1, 3-cycloaddition of carbonyl ylides under microwave irradiation

Synlett [© Georg Thieme Verlag], Volume: 23 Issue: 10 Pages: 1459-1462

Valentina Mussi, Paola Fanzio, Luca Repetto, Giuseppe Firpo, Sara Stigliani, Gian Paolo Tonini, Ugo Valbusa

“DNA-Dressed NAnopore” for complementary sequence detection

Biosensors and Bioelectronics [Elsevier], Volume: 29 Issue: 1 Pages: 125-131

Michele Menotta, Rita Crinelli, Elisa Carloni, Valentina Mussi, Ugo Valbusa, Mauro Magnani

Binding force measurement of NF-κB–ODNs interaction: An AFM based decoy and drug testing tool

Biosensors and Bioelectronics [Elsevier], Volume: 28 Issue: 1 Pages: 158-165

M Menotta, R Crinelli, E Carloni, V Mussi, U Valbusa, M Magnani

binding force measurement of Nf-kb-Odns interaction: an Afm based decoy and drug testing tool: p33. 18

The Febs Journal [The FEBS Journal], Volume: 278 Pages: 439

Paola Fanzio, Valentina Mussi, Chiara Manneschi, Elena Angeli, Giuseppe Firpo, Luca Repetto, Ugo Valbusa

DNA detection with a polymeric nanochannel device

Lab on a Chip [Royal Society of Chemistry], Volume: 11 Issue: 17 Pages: 2961-2966

RM Montereali, F Bonfigli, V Mussi, E Nichelatti, A Santoni, S Scaglione

Optical investigation of metallic lithium colloids and F-centres in ion-assisted LiF thin films

IOP Conference Series: Materials Science and Engineering [IOP Publishing], Volume: 15 Issue: 1 Pages: 012017

V Mussi, P Fanzio, L Repetto, G Firpo, P Scaruffi, S Stigliani, Michele Menotta, Mauro Magnani, GP Tonini, U Valbusa

Electrical characterization of DNA-functionalized solid state nanopores for bio-sensing

Journal of Physics: Condensed Matter [IOP Publishing], Volume: 22 Issue: 45 Pages: 454104

V Mussi, C Biale, Sonia Visentin, Nadia Barbero, M Rocchia, U Valbusa

Raman analysis and mapping for the determination of COOH groups on oxidized single walled carbon nanotubes

Carbon [Pergamon], Volume: 48 Issue: 12 Pages: 3391-3398

Adriana Albini, Valentina Mussi, Alessandro Parodi, Agostina Ventura, Elisa Principi, Sara Tegami, Massimiliano Rocchia, Enrico Francheschi, Ilaria Sogno, Rosaria Cammarota, Giovanna Finzi, Fausto Sessa, Douglas McClain Noonan, Ugo Valbusa

Interactions of single-wall carbon nanotubes with endothelial cells

Nanomedicine: Nanotechnology, Biology and Medicine [Elsevier], Volume: 6 Issue: 2 Pages: 277-288

V Mussi, P Fanzio, L Repetto, G Firpo, P Scaruffi, S Stigliani, GP Tonini, U Valbusa

DNA-functionalized solid state nanopore for biosensing

Nanotechnology [IOP Publishing], Volume: 21 Issue: 14 Pages: 145102

Sonja Visentin, Nadia Barbero, Simone Musso, Valentina Mussi, Chiara Biale, Rebecca Ploeger, Guido Viscardi

A sensitive and practical fluorimetric test for CNT acidic site determination

Chemical communications [The Royal Society of Chemistry], Volume: 46 Issue: 9 Pages: 1443-1445

V Mussi, P Fanzio, L Repetto, G Firpo, U Valbusa, P Scaruffi, S Stigliani, GP Tonini

Solid state nanopores for gene expression profiling

Superlattices and Microstructures [Academic Press], Volume: 46 Issue: 1-2 Pages: 59-63

GIUSEPPE Cama, F Barberis, R Botter, P Cirillo, M Capurro, R Quarto, S Scaglione, E Finocchio, V Mussi, U Valbusa

Preparation and properties of macroporous brushite bone cements

Acta biomaterialia [Elsevier], Volume: 5 Issue: 6 Pages: 2161-2168

Elena Angeli, Renato Buzio, Giuseppe Firpo, Raffaella Magrassi, Valentina Mussi, Luca Repetto, Ugo Valbusa

Nanotechnology applications in medicine

Tumori Journal [SAGE Publications], Volume: 94 Issue: 2 Pages: 206-215

R Felici, NM Jeutter, V Mussi, F Buatier de Mongeot, C Boragno, U Valbusa, A Toma, Y Wei Zhang, C Rau, IK Robinson

In situ study of the dewetting behavior of Ni-films on oxidized Si (001) by GISAXS

Surface science [North-Holland], Volume: 601 Issue: 18 Pages: 4526-4530

V Mussi, RM Montereali, E Nichelatti, C Boragno, F Buatier de Mongeot, U Valbusa

Broad band light-emitting nanostructured substrates by ion beam irradiation of lithium fluoride crystals

Surface science [North-Holland], Volume: 601 Issue: 13 Pages: 2746-2749

RM Montereali, F Bonfigli, T Marolo, V Mussi, E Nichelatti

Toward control of point defects in lithium fluoride thin layers

physica status solidi c [WILEY‐VCH Verlag], Volume: 4 Issue: 3 Pages: 864-869

V Mussi, F Granone, C Boragno, F Buatier de Mongeot, U Valbusa, T Marolo, RM Montereali

Surface nanostructuring and optical activation of lithium fluoride crystals by ion beam irradiation

Applied physics letters [American Institute of Physics], Volume: 88 Issue: 10 Pages: 103116

Elisa Mele, Francesca Di Benedetto, Roberto Cingolani, Dario Pisignano, Andrea Toma, Francesco Buatier de Mongeot, Renato Buzio, Corrado Boragno, Giuseppe Firpo, Valentina Mussi, Ugo Valbusa

Nanostructuring polymers by soft lithography templates realized via ion sputtering

Nanotechnology [IOP Publishing], Volume: 16 Issue: 11 Pages: 2714

Francesca Granone, V Mussi, A Toma, S Orlanducci, ML Terranova, C Boragno, F Buatier de Mongeot, U Valbusa

Ion sputtered surfaces as templates for carbon nanotubes alignment and deformation

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms [North-Holland], Volume: 230 Issue: 1-4 Pages: 545-550

V Mussi, RM Montereali, P Moretti, J Mugnier, E Nichelatti, F Somma, B Jacquier

Active waveguides produced in lithium fluoride by He+ implantation

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms [North-Holland], Volume: 230 Issue: 1-4 Pages: 257-261

S Scaglione, RM Monterealib, V Mussib, E Nichelatti

F-colour centers and lithium nano-clusters in ion-beam assisted lif thin films

Journal of Optoelectronics and Advanced Materials [], Volume: 7 Issue: 1 Pages: 207-213

Francesca Ceccacci, Simona Sennato, Edoardo Rossi, Raffaele Proroga, Stefano Sarti, Marco Diociaiuti, Stefano Casciardi, Valentina Mussi, Alessia Ciogli, Federico Bordi, Giovanna Mancini, Cecilia Bombelli

Synthesis and Characterization of Mitochondria-Targeted Triphenylphosphonium Bolaamphiphiles

Mitochondrial Medicine [Humana, New York, NY], Pages: 27-47

Ugo Valbusa, Luca Repetto, Giuseppe FIrpo, Valentina Mussi, Paola Fanzio, Chiara Manneschi, Gian Paolo Tonini, Paola Scaruffi, Sara Stigliani, Michele Menotta, Mauro Magnani

Device and single-molecule analysis method by means of detection of the collisions of a target molecule on functionalized nanopores

US20140202857 [],

Nadia Barbero, Sonia Visentin, V Mussi, C Biale, U Valbusa, S Musso, R Ploeger, Guido Viscardi

A sensitive and practical fluorimetric test for CNTs acidic sites determination

Giornate Italo-Francesi di Chimica [SCI], Pages: CO-14-CO-14

C Biale, V Mussi, Sonia Visentin, Nadia Barbero, U Valbusa

Evaluation of surface carboxylic groups for oxidized Single Walled Carbon Nanotubes using Raman Spectroscopy

Giornate Italo-Francesi di Chimica [SCI], Pages: CP-14-CP-14

Valentina Mussi, Paola Fanzio, Luca Repetto, Giuseppe Firpo, Ugo Valbusa, Sara Stigliani, Paola Scaruffi, GianPaolo Tonini

DNA-functionalized nanopores for single molecule analysis

2009 9th IEEE Conference on Nanotechnology (IEEE-NANO) [IEEE], Pages: 682-684

Chiara Biale, Valentina Mussi, Ugo Valbusa, Sonja Visentin, Guido Viscardi, Nadia Barbero, Nicoletta Pedemonte, Luis Galietta

Carbon nanotubes for targeted drug delivery

2009 9th Ieee Conference on Nanotechnology (Ieee-Nano) [IEEE], Pages: 644-646

Paola Fanzio, Elena Angelí, Valentina Mussi, Ugo Valbusa, Paola Rivolo, Francesca Frascella, Candido Fabrizio Pirri

Development of a polymeric device for gene expression profiling

2009 9th IEEE Conference on Nanotechnology (IEEE-NANO) [IEEE], Pages: 613-615