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In this work, two procedures for fabrication of polymeric microneedles based on direct photolithography, without any etching or molding process, are reported. Polyethylene glycol (average molecular weight 250 Da), casted into a silicone vessel and exposed to ultraviolet light (365 nm) through a mask, cross-links when added by a commercial photocatalyzer. By changing the position of the microneedles support with respect to the vessel, different shapes and lengths can be achieved. Microneedles from a hundred microns up to two millimeters have been obtained just tuning the radiation dose, by changing the exposure time (5–15 s) and/or the power density (9–18 mW/cm 2) during photolithography. Different microneedle shapes, such as cylindrical, conic or lancet-like, for specific applications such as micro-indentation or drug delivery, are demonstrated. View Full-Text
Multidisciplinary Digital Publishing Institute
Publication date: 
1 Dec 2015

Principia Dardano, Alessandro Caliò, Vincenza Di Palma, Maria Fortuna Bevilacqua, Andrea Di Matteo, Luca De Stefano

Biblio References: 
Volume: 8 Issue: 12 Pages: 8661-8673