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The study of the mechanisms underlying the uptake and release of bioactive molecules from stimuli-responsive nanoparticles is the key to their application in biomedical fields. Here, we present the pH-controlled uptake and release of two chemically different solutes from newly synthesized nanogels, showing their potential as pH-controlled dual drug delivery systems. Nanogels were synthesized by emulsion copolymerization of methacrylic acid (MAA) and methyl acrylate (MA), and then characterized by FT-IR, 1H NMR, and dynamic light scattering (DLS). To study the encapsulation and delivery properties of PMA-PMAA nanogels, a hydrophobic thiophene fluorophore (TF) and a cationic drug, doxorubicin (DX), were chosen. The uptake and release experiments were run at different pH values and monitored by absorption and both steady-state and time-resolved photoluminescence (PL) spectroscopy. Interestingly …
American Chemical Society
Publication date: 
25 Aug 2011

Simona Argentiere, Laura Blasi, Giovanni Morello, Giuseppe Gigli

Biblio References: 
Volume: 115 Issue: 33 Pages: 16347-16353
The Journal of Physical Chemistry C