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Hydrotalcites-like compounds, also known as anionic clays or layered double hydroxides, represent the only example of lamellar solid with positively charged layers and exchangeable interlayer anions. In this study, a nanostructured HTlc with formula [Zn0.72Al0.28(OH)2] Br0.28·0.69 H2O was used as inorganic drug delivery system for anticancer therapy. Two different molecules were selected for being separately intercalated into ZnAl-HTlc: the anticancer drug norcantharidin, known for inducing cell cycle arrest at G2/M phase, and the tetra-sulfonated aluminum phthalocyanine, a photosensitizer used in anticancer photodynamic therapy. The obtained hybrid ZnAl-HTlc, were characterized in terms of X-ray powder diffraction pattern, thermogravimetric analysis, scanning electron microscopy, drug release profile, in vitro cytotoxicity, and ability to produce ROS and 1O2 upon light irradiation. Our results clearly …
American Chemical Society
Publication date: 
2 Nov 2018

Cecilia Martini, Claudia Ferroni, Marzia Bruna Gariboldi, Anna Donnadio, Annalisa Aluigi, Giovanna Sotgiu, Fabiola Liscio, Paolo Dambruoso, Maria Luisa Navacchia, Tamara Posati, Greta Varchi

Biblio References: 
Volume: 1 Issue: 11 Pages: 6387-6397
ACS Applied Nano Materials