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Several studies propose nanoparticles for tumor treatment, yet little is known about the fate of nanoparticles and intimate interactions with the heterogeneous and ever-evolving tumor environment. The latter, rich in extracellular matrix, is responsible for poor penetration of therapeutics and represents a paramount issue in cancer therapy. Hence new strategies start aiming to modulate the neoplastic stroma. From this perspective, we assessed the efficacy of 19 nm PEG-coated iron oxide nanocubes with optimized magnetic properties to mediate mild tumor magnetic hyperthermia treatment. After injection of a low dose of nanocubes (700 μg of iron) into epidermoid carcinoma xenografts in mice, we monitored the effect of heating nanocubes on tumor environment. In comparison with the long-term fate after intravenous administration, we investigated spatiotemporal patterns of nanocube distribution, evaluated the …
American Chemical Society
Publication date: 
27 May 2014

Jelena Kolosnjaj-Tabi, Riccardo Di Corato, Lenaic Lartigue, Iris Marangon, Pablo Guardia, Amanda KA Silva, Nathalie Luciani, Olivier Clement, Patrice Flaud, Jaykrishna V Singh, Paolo Decuzzi, Teresa Pellegrino, Claire Wilhelm, Florence Gazeau

Biblio References: 
Volume: 8 Issue: 5 Pages: 4268-4283
ACS nano