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Cancer still poses a global threat, since a lot of tumors remain untreatable despite all the available chemotherapeutic drugs, whose side effects, it must also be noted, still raise concerns. The antitumoral properties of marine seaweeds make them a potential source of new, less toxic, and more active antitumoral agents. Furthermore, these natural extracts can be combined with nanotechnology to increase their efficacy and improve targeting. In this work, a Codium tomentosum (CT) aqueous extract was employed for the green synthesis of gold nanoparticles ([email protected]). The complete characterization of [email protected] was performed by UV-Vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, Zeta potential, electron microscopy, X-ray powder diffraction (XRD), high-performance steric exclusion chromatography (HPSEC), and by the determination of their antioxidant capacity. The antiproliferative activity of [email protected] was then tested in hepatic (HEPG-2) and pancreatic (BxPC-3) cell lines. Their potential capacity as enhancers of gemcitabine, a drug frequently used to treat both types of tumors, was also tested. The activity of [email protected] was compared to the activity of the CT extract alone. A synergistic effect with gemcitabine was proven for HEPG-2. Our results showed that gold nanoparticles synthesized from seaweed extracts with antitumoral activity could be a good gemcitabine enhancer.
Multidisciplinary Digital Publishing Institute
Publication date: 
1 Jan 2023

Noelia González-Ballesteros, Immacolata Maietta, Raquel Rey-Méndez, M Carmen Rodríguez-Argüelles, Mariano Lastra-Valdor, Antonella Cavazza, Maria Grimaldi, Franca Bigi, Rosana Simón-Vázquez

Biblio References: 
Volume: 21 Issue: 1 Pages: 20
Marine Drugs