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Microneedles are largely applied in biomedicine, both in diagnostics and therapeutics, since they can be considered the perfect interface between patient and sensing/dispensing devices. In this paper, we present an electro-chemical biosensor based on polymeric microneedles array for the measure of glucose level in interstitial fluids. The microneedles array has been fabricated by photolithography of a polymer, PolyEthylene Glycol DiAcrylate hydrogel, mixed with an enzyme, Glucose oxidase, and a redox mediator, the Vynilferrocene. The microneedles array acts as a working electrode when gold plated by sputtering and their tips have been etched to create a sensitive area. The redox reaction with glucose creates a charge transfer, enhanced by the redox mediator, resulting in a current proportional to the glucose concentration.
Publication date: 
20 Apr 2016

Principia Dardano, A Caliò, Vincenza Di Palma, MF Bevilacqua, Andrea Di Matteo, Luca De Stefano

Biblio References: 
Pages: 1-5
2016 IEEE Sensors Applications Symposium (SAS)