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BackgroundDiatomite is a natural porous biomaterial of sedimentary origin, formed by fragments of diatom siliceous skeletons, called “frustules”. Due to large availability in many areas of the world, chemical stability, and non-toxicity, these fossil structures have been widespread used in lot of industrial applications, such as food production, water extracting agent, production of cosmetics and pharmaceutics. However, diatomite is surprisingly still rarely used in biomedical applications. In this work, we exploit diatomite nanoparticles for small interfering ribonucleic acid (siRNA) transport inside human epidermoid cancer cells (H1355).MethodsMorphology and composition of diatomite microfrustules (average size lower than 40 μm) are investigated by scanning electron microscopy equipped by energy dispersive X-ray spectroscopy, Fourier transform infrared analysis, and photoluminescence measurements. Nanometric …
Publication date: 
1 Dec 2014

Ilaria Rea, Nicola M Martucci, Luca De Stefano, Immacolata Ruggiero, Monica Terracciano, Principia Dardano, Nunzia Migliaccio, Paolo Arcari, Rosarita Taté, Ivo Rendina, Annalisa Lamberti

Biblio References: 
Volume: 1840 Issue: 12 Pages: 3393-3403
Biochimica et Biophysica Acta (BBA)-General Subjects