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BackgroundBreast cancer (BC) survival rates in Europe reach about 70% suggesting a large residual risk. Women with BC may suffer from other chronic conditions (diabetes) which increase the risk of recurrence and reduce survival. Mechanisms of BC include hyperglycemia, hyperinsulinemia, high estrogen levels, insulin‐like growth factors (IGF), inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods have low glycemic and insulinemic potentials and have been associated with lower BC risk. Moderate physical activity post‐diagnosis reduces BC recurrence and mortality which is partly explained by reduced insulin and estrogen levels. Vitamin D alters genes implicated in cell differentiation/apoptosis and high serum vitamin D levels have shown improved BC survival. Dietary interventions have been …
The Federation of American Societies for Experimental Biology
Publication date: 
1 Apr 2016

Livia Silvia Augustin, Massimo Libra, Anna Crispo, Maria Grimaldi, Saverio Candido, Luca Falzone, Michelino De Laurentiis, Cedric F Garland, David JA Jenkins, Cyril WC Kendall, Gennaro Ciliberto, Maurizio Montella

Biblio References: 
Volume: 30 Pages: 1168.2-1168.2
The FASEB Journal