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Lanthanide-doped yttrium oxide nanoparticles can display selective upconversion properties, rendering them invaluable in the field of nanomedicine for both sensing and diagnostics. Different syntheses of Er: Y 2 O 3 and Nd: Y 2 O 3 nanoparticles (NPs) were studied and optimized to obtain small particles of regular shape and good crystallinity. The morphological and compositional characterizations of the nanoparticles were obtained with different techniques and showed that both Er: Y 2 O 3 and Nd: Y 2 O 3 NPs were well dispersed, with dimensions of the order of a few tens of nanometers. The photoluminescence and cathodoluminescence measurements showed that both Er: Y 2 O 3 and Nd: Y 2 O 3 NPs had good emission as well as upconversion. The nanophosphors were functionalized by a pegylation procedure to suppress unwanted reactions of the NPs with other biological components, making the NP systems biocompatible and the NPs soluble in water and well dispersed. The pegylated core/shell nanoparticles showed the same morphological and optical characteristics as the core, promoting their strategic role as photoactive material for theragnostics and biosensing.
Multidisciplinary Digital Publishing Institute
Publication date: 
1 Jan 2023

Regina Maria Chiechio, Rosalia Battaglia, Angela Caponnetto, Ester Butera, Giorgia Franzò, Riccardo Reitano, Michele Purrello, Marco Ragusa, Davide Barbagallo, Cristina Barbagallo, Cinzia Di Pietro, Valérie Marchi, Maria José Lo Faro, Annalinda Contino, Giuseppe Maccarrone, Paolo Musumeci

Biblio References: 
Volume: 11 Issue: 1 Pages: 20