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Genomic deoxyribonucleic acid (DNA) stores and carries the information required to maintain and replicate cellular life. While much efforts have been devoted in decoding the sequence of DNA basis to detect the genetic mutations related to cancer disease, it is becoming clear that physical properties, like structural conformation, stiffness and shape, can play an important role to recognize DNA modifications. Here, silver-coated silicon nanowires (Ag/SiNWs) are exploited as Raman spectroscopic platform to easily discriminate healthy and cancer genomic DNA, extracted from human normal skin and malignant melanoma cells, respectively. In particular, aqueous DNA droplets are directly deposited onto a forest of Ag/SiNWs and Raman maps are acquired after sample dehydration. By applying principal component analysis (PCA) to the Raman spectra collected within the droplets, healthy and cancer cell DNA can be …
Publication date: 
1 Mar 2021

Valentina Mussi, Mario Ledda, Davide Polese, Luca Maiolo, Debadrita Paria, Ishan Barman, Maria Grazia Lolli, Antonella Lisi, Annalisa Convertino

Biblio References: 
Volume: 122 Pages: 111951
Materials Science and Engineering: C