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In this paper we demonstrate the implementation of a micro-scaled integrated system with the aim to sort, estimate and monitor the biomass of living cancer cells suspended in a culture medium. For this purpose, a 3D microfluidic network is designed to route small volumes of biological samples to the testing sites and dielectric spectroscopy is chosen as investigation method. Comparative electrical analyses are guaranteed by the separation of sole medium and medium-cells mixture in two different areas of the chip. A polyimide-based micro-sieve, placed between two microfluidic channels, is used to perform cell filtering and sorting. Two couples of thin-film metal electrodes ensure the comparative dielectric measurements of the separated materials. Preliminary experiments were carried out in order to test the microfluidics and demonstrate its particle-separating capabilities. The first results prove the robustness of …
Publication date: 
13 Jun 2019

Alessio Buzzin, Lorenzo Iannascoli, Marco Muzi, Andrea Veroli, Domenico Caputo, Giampiero de Cesare, Luca Maiolo, Francesco Maita, Giulia Ricci

Biblio References: 
Pages: 224-227
2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI)