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Microparticles of colloidal CaCO3 cores coated with Layer-by-Layer (LbL) self-assembled oppositely charged biocompatible (PSS\PAH) or biodegradable (DXS\PRM) polyelectrolytes and hollow capsules, obtained after removal of carbonate cores by EDTA, were fabricated and characterised by z-Potential, Scanning Electron microscopy (SEM) and Scanning Force Microscopy (SFM).Fluorescently-labelled polymer layers coated onto carbonate cores were employed for evaluating cell uptake efficiency and confocal laser scanning microscopy (CLSM) has been used to confirm pre-formed biodegradable multilayers dissolution.The internalisation efficiency and cytotoxicity of polymer capsules were studied in three different adherent cells (e.g.HeLa human cervice cancer), MCF-7 (human breast cancer) and B104 (murine neuroblastoma).The cyto-viability was preserved, indicating the cell safety and tolerability of these …
Publication date: 
1 Jun 2009

Stefano Leporatti, Ilaria Elena Palamà, Addolorata Maria Luce Coluccia, Carlo Gambacorti-Passerini, Antonio della Torre, Viviana Vergaro, Elisabetta Perrone, Roberto Cingolani, Ross Rinaldi, CNR Primo Ricercatore

Biblio References: 
Pages: 542-542
BIT ‘s2nd Annual World Cancer Congess-2009 (2009 第二届癌症大会)