-A A +A
Photothermal therapy (PTT) assisted by nanomaterials is a promising minimally invasive technique for cancer treatment. Here, we explore the PTT properties of a silicon-and gold-based nanostructured platform suitable for being directly integrated in fibre laser systems rather than injected into the human body, which occurs for the most commonly unreported PTT nanoagents. In particular, the photothermal properties of an array of disordered silicon nanowires coated by a thin gold film (Au/SiNWs) were tested on a monolayer of human colon adenocarcinoma cells (Caco-2) irradiated with a 785 nm laser. Au/SiNWs allowed an efficient photothermal action and simultaneous monitoring of the process evolution through the Raman signal coming from the irradiated cellular zone. Strong near infra-red (NIR) absorption, overlapping three biological windows, cell-friendly properties and effective fabrication technology make …
IOP Publishing
Publication date: 
10 Aug 2018

Annalisa Convertino, Valentina Mussi, Luca Maiolo, Mario Ledda, Maria Grazia Lolli, Fabio Antonio Bovino, Guglielmo Fortunato, Massimiliano Rocchia, Antonella Lisi

Biblio References: 
Volume: 29 Issue: 41 Pages: 415102