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In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.
Springer Singapore
Publication date: 
10 Nov 2017

Maria Antonietta Panaro, Alessandra Aloisi, Giuseppe Nicolardi, Dario Domenico Lofrumento, Francesco De Nuccio, Velia La Pesa, Antonia Cianciulli, Rosaria Rinaldi, Rosa Calvello, Vania Fontani, Salvatore Rinaldi

Biblio References: 
Pages: 1-13
Neuroscience Bulletin