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Protein glycosylation is the most common epiproteomic modification involved in numerous physiological and pathological processes. Previous studies reported strong associations between human plasma N-glycans and age, prompting us to evaluate the potential application of this biological phenomenon in the field of forensics. Blood from 526 blood donors from different parts of Croatia was collected on bloodstain cards during the period 2004–2007 and stored at 4°C for 6–9 years. Glycosylation profiles of the bloodstains were analysed using hydrophilic interaction ultra performance liquid chromatography (HILIC-UPLC) and divided into 38 glycan groups (GP1-GP38). A statistically significant correlation between N-glycan profiles of bloodstains and chronological age was found and a statistical model that can be used for the age prediction was designed (Age = 75.59 – 5.15 × (GP4)2+ 17.07 × GP6 – 5 …
Springer Berlin Heidelberg
Publication date: 
1 Sep 2015

Ivan Gudelj, Toma Keser, Frano Vučković, Vedrana Škaro, Sandra Šupraha Goreta, Tamara Pavić, Jerka Dumić, Dragan Primorac, Gordan Lauc, Olga Gornik

Biblio References: 
Volume: 129 Issue: 5 Pages: 955-961
International journal of legal medicine